A subchronic toxicity test of ethyl acetate extract from endophytic fungus Penicillium sp. of kunyit putih (Curcuma zedoaria) against Swiss albino mice

Muharni, Muharni and Yohandini , Heni (2018) A subchronic toxicity test of ethyl acetate extract from endophytic fungus Penicillium sp. of kunyit putih (Curcuma zedoaria) against Swiss albino mice. Journal of Chinese Pharmaceutical Sciences, 27 (2). pp. 123-130. ISSN 1003-1057

[img]
Preview
PDF
Download (1164Kb) | Preview

    Abstract

    Ethyl acetate extract of endophytic fungus from Penicillium sp. of kunyit putih showed antibacterial activity in vivo but no acute toxicity. However, the extract may have toxic effects on major organs for long-term consumption. This study was carried out in order to test sub-chronic toxicity of the ethyl acetate from endophytic fungus Penicillium sp. of kunyit putih against mice (Mus musculus). A total of 50 male mice were divided into five groups. Groups I, II, III and IV were orally administered with ethyl acetate extracts of 250, 500, 1000 and 2000 mg/kg body weight (BW), respectively. Group V was used as a control without extract treatment. A toxic symptom was observed by analyzing several parameters, namely change in BW, hematologic and biochemical properties (SGOT & SGPT), macroscopic organs, and relative organ weight. The results showed that there was toxic symptom and statistically significant difference in the parameters of SGOT, SGPT and heart weight between treated and control groups. Based on analysis, we concluded that ethyl acetate extract from endophytic fungus Penicillium sp. of kunyit putih had subchronic toxicity effect.

    Item Type: Article
    Subjects: Q Science > QD Chemistry
    Divisions: Faculty of Mathematics and Natural Sciences > Department of Chemistry
    Depositing User: Dr Elfita Elfita
    Date Deposited: 14 May 2018 10:06
    Last Modified: 14 May 2018 10:06
    URI: http://eprints.unsri.ac.id/id/eprint/7887

    Actions (login required)

    View Item