Correlation Between Hypoxia Inducible Factor-1α and Vesicular Endothelial Growth Factor in Male Wistar Rat Brain Tissue After Anaerobic Exercise

Flora, Rostika Correlation Between Hypoxia Inducible Factor-1α and Vesicular Endothelial Growth Factor in Male Wistar Rat Brain Tissue After Anaerobic Exercise. Trends in Medical Research. ISSN 1819-3587

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    Abstract

    During physical activity, oxygen reduction leading to hypoxia affects brain cell metabolisms, induces stabilization of Hypoxia Inducible Factor-1α (HIF-1α) and up-regulate Vesicular Endothelial Growth Factor (VEGF). This study aimed to investigate the correlation of HIF-1α and VEGF of brain tissue in male wistar rat after anaerobic exercise. Twenty four rats were divided into four groups: control, 1x, 3x and 7x in a week of anaerobic exercise. A rat treadmill was used at speed 35 m minG1, 20 min for every anaerobic exercise. The HIF-1α and VEGF level were measured by ELISA. The correlation between HIF-1α and VEGF was analyzed using Pearson test. The HIF-1α and VEGF level increased in 1x and 3x a week of anaerobic exercise. The highest HIF-1α and VEGF level were observed in 1x a week of anaerobic exercise. Pearson test between HIF-1α and VEGF showed r = 0.709 and p = 0.000. These findings showed that HIF-1α and VEGF are correlated and anaerobic exercise affects HIF-1α and VEGF level

    Item Type: Article
    Subjects: R Medicine > R Medicine (General)
    Divisions: Faculty of Medicine
    Depositing User: Sujianto Sujianto
    Date Deposited: 06 Jan 2016 17:23
    Last Modified: 06 Jan 2016 17:23
    URI: http://eprints.unsri.ac.id/id/eprint/6005

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