Antiplasmodial and other constituents from four Indonesian Garcinia spp.

Elfita, Elfita and Muharni, Muharni and Latief , Madyawati and Darwati, Darwati and Widiyantoro , Ari and Supriyatna, Supriyatna and Bahti , Husein H. and Dachriyanus, Dachriyanus and Cos , Paul and Maes , Louis and Foubert, Kenne and Apers , Sandra and Pieters , Luc (2009) Antiplasmodial and other constituents from four Indonesian Garcinia spp. Phytochemistry, 70 (7). pp. 907-912. ISSN 0031-9422

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    Abstract

    Phytochemical investigations of four Garcinia spp. from Indonesia, i.e. Garcinia griffithii T. Anderson, Garcinia celebica L., Garcinia cornea L. and Garcinia cymosa K. Schum (Clusiaceae), have resulted in the isolation of a xanthone, 1,5-dihydroxy-3,6-dimethoxy-2,7-diprenylxanthone, 1,7-dihydroxyxanthone, isoxanthochymol, β-sitosterol-3-O-b-D-glucoside and stigmasterol-3-O-β-D-glucoside from the stem bark of G. griffithii; friedelin and 3β-hydroxy-23-oxo-9,16-lanostadien-26-oic acid or garcihombronane D from leaves of G. celebica; 23-hydroxy-3-oxo-cycloart-24-en-26-oic acid and epicatechin from stem bark of G. cornea; (±)-morelloflavone, morelloflavone-7-O-b-D-glucoside or fukugiside, the triterpene 3β-hydroxy-5-glutinen-28-oic acid and canophyllol from stem bark of G. cymosa. The xanthone and garcihombronane D displayed a selective activity against Plasmodium falciparum; isoxanthochymol and the triterpene b-hydroxy-5-glutinen-28-oic acid a broad but non-selective antiprotozoal activity.

    Item Type: Article
    Subjects: Q Science > QD Chemistry
    Divisions: Faculty of Mathematics and Natural Sciences > Department of Chemistry
    Depositing User: Dr Elfita Elfita
    Date Deposited: 03 Nov 2015 12:31
    Last Modified: 03 Nov 2015 12:31
    URI: http://eprints.unsri.ac.id/id/eprint/5877

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