Bone mass regulation of leptin and postmenopausal osteoporosis with obesity

Siswo, Legiran (2012) Bone mass regulation of leptin and postmenopausal osteoporosis with obesity. Clinical Cases in mineral and bone metabolism, IX (3). pp. 145-149. ISSN 1971-3266

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    Background Leptin has been known to play a role in weight regulation through food intake and energy expenditure. Leptin also has an important role in bone metabolism. The role of leptin is determined by leptin receptors, either central or peripheral to the bones. Design We discuss the role of leptin on bone and molecular genetics of osteoporosis in postmenopausal obese women. Results The role of leptin in bone preserves bone mineral density (BMD) through increased OPG levels leading to bind RANKL, resulting in reducing osteoclast activity. The estrogen role on bone is also mediated by RANKL and OPG. In postmenopausal women who have estrogen deficiency, it increases the rate of RANKL, which increases osteoclastogenesis. Obese individuals who have a high level of leptin will be effected by bone protection. Conclusion There are similarities in the mechanism between estrogen and leptin in influencing the process of bone remodeling. It may be considered that the role of estrogen can be replaced by leptin. Molecular genetic aspects that play a role in bone remodeling, such as leptin, leptin receptors, cytokines (e.g. RANK, RANKL, and OPG), require further study to be useful, especially regarding osteoporosis therapy based on genetic analysis. Keywords: leptin, leptin receptor, estrogen, RANKL, OPG

    Item Type: Article
    Subjects: R Medicine > R Medicine (General)
    Divisions: Faculty of Medicine
    Depositing User: Doktor Legiran Siswo
    Date Deposited: 31 Jul 2015 21:27
    Last Modified: 31 Jul 2015 21:27

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