MOLECULAR MECHANISMS OF RADICULAR CYST FORMATION

Chairani, Shanty (2011) MOLECULAR MECHANISMS OF RADICULAR CYST FORMATION. PDGI (Persatuan Dokter Gigi Indonesia).

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    Abstract

    Background : Radicular cysts are the most common cystic lesions affecting the jaws. They are most commonly found at the apices of teeth with necrotic pulps or defective root canal filling. It presupposes that physical, chemical or bacteria injury resulting in death of pulp followed by stimulation of epithelial cell rests of Malassez, which normally can be found in periodontal ligament. But it still unclear how are the epithelial cell rests stimulated to proliferate and how does the bone destruction occurs throughout cyst growth. Aims : The purpose of this study is to give a short overview of the molecular mechanisms of radicular cyst formation. Content : It was reported that the inflamed cells in periapical of necrotic teeth can induce the production of proinflamma tory cytokines and growth factors, which those factors mediate proliferation of epithelial cell rests. As the cysts develop, the surrounding bone will get resorbed, The expression of receptor activator NFĸB-ligand (RANKL) and matrix metalloproteinases (MMP) were found in cyst cavity, which suggest the significance of these molecules in mediate bone resorption in inflammatory periapical lesions. Conclusion : Radicular cysts are most likely induced by the initiation of an inflammatory focus of necrotic teeth which trigger proliferation of epithelial and bone resorption.

    Item Type: Book
    Subjects: R Medicine > RK Dentistry
    Divisions: Faculty of Medicine > Department of Dentistry
    Depositing User: drg Shanty Chairani
    Date Deposited: 08 Aug 2015 01:35
    Last Modified: 08 Aug 2015 01:35
    URI: http://eprints.unsri.ac.id/id/eprint/5151

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