Small dense LDL as risk factor of cardiovascular disease in prediabetes of first degree relative from patients with type 2 diabetes mellitus

Liana, Phey and Suryaatmadja, Marzuki (2013) Small dense LDL as risk factor of cardiovascular disease in prediabetes of first degree relative from patients with type 2 diabetes mellitus. Pactoconvex Niagatama, Jakarta. ISBN 978-602-14796-0-5

[img]
Preview
PDF
Download (3150Kb) | Preview

    Abstract

    Background : Prediabetic patients are considered as prone to cardiometabolic risk because they can progress to diabetes mellitus (DM) and cardiovascular disease (CVD). Among lipid lipoprotein risk factors, sd-LDL is the most atherogenic lipoprotein. Triglyceride/HDL-cholesterol (Tg/HDL-C) ratio is considered parallel with sd-LDL level. Nevertheless, there is no data about sd-LDL level and Tg/HDL-C ratio in prediabetic and normoglycemic subgroups of first-degree relatives from patients with type 2 diabetes mellitus (T2DM) in Indonesia. The aim of this study was to prove that prediabetic subgroup have higher sd-LDL level compared to normoglycemic subgroup and Tg/HDL-C ratio is correlated well with sd-LDL level. Materials and methods : This cross sectional study is consisted of 96 subjects of first-degree relatives from patients with T2DM in Cipto Mangunkusumo General Hospital, Jakarta, which was divided to prediabetic and normoglycemic subgroups of 48 subjects each. Prediabetes was diagnosed according to ADA 2003 revised criteria. sd-LDL was measured as sd-LDL-cholesterol (sd-LDL-C) quantitatively by direct homogenous enzymatic method. Triglyceride was measured by enzymatic method and HDL-C was measured by direct homogenous enzymatic method. Results : Both sd-LDL-C level and Tg/HDL-C ratio were significantly higher in prediabetic subgroup compared to normoglycemic subgroup [30.5 (14.4 13 72.0) mg/dL vs 19.0 (10.1 13 34.0) mg/dL); p<0.001 and 2.70 (0.77 13 6.63) vs 1.49 (0.86 13 3.16); p<0.001]. There was significantly strong correlation between sd-LDL-C level and Tg/HDL-C ratio [r=0.806, p<0.001]. Conclusions : We concluded that among first-degree relatives from patients with T2DM, the prediabetic subgroup has higher CVD risk compared to normoglycemic subgroup based on sd-LDL-C level and Tg/HDL-C ratio. It is recommended to measure sd-LDL-C level in prediabetic patients. If sd-LDL-C level examination is unavailable, Tg/HDL-C ratio can be used as a substitute parameter. Keywords : Prediabetes, sd-LDL-C, Tg/HDL-C ratio, CVD risk.

    Item Type: Book
    Subjects: R Medicine > R Medicine (General)
    Divisions: Faculty of Medicine > Department of Medicine
    Depositing User: dr Phey Liana
    Date Deposited: 21 Jul 2014 21:14
    Last Modified: 21 Jul 2014 21:14
    URI: http://eprints.unsri.ac.id/id/eprint/4645

    Actions (login required)

    View Item