HIF-1α Concentration and Heart Muscle Histopathology of Wistar Rats Induced by Aerobic and Anaerobic Activities

Flora, Rostika (2012) HIF-1α Concentration and Heart Muscle Histopathology of Wistar Rats Induced by Aerobic and Anaerobic Activities. In: 3rd International Nursing Conference. Universitas Padjajaran. ISBN 978-602-7571-00-6

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    Background Physical activity besides improving cardiac function, can also lead to sudden death, which is often occurred in the sport event itself. Some studies suggested that most are caused by myocardial infarct. During physical activity increased demand of oxygen required for energy metabolism. If the increasing demand is not fulfilled by the oxygen supply, then the organism will undergo hypoxia state. It is not yet known, whether hypoxia occurs in heart muscle, considering the heart must works hard in this condition. During physical activity molecular adaptation and systemic adaptation will occur. Response of heart muscle to systemic adaptation is well known. However the molecular adaption of this organ still need to be studied in details. Method In this study, certain number of rats were divided into 3 major groups namely control group, aerobic activity group and anaerobic group . As physical activity each animal must run on a treadmill (20 m / min for 30 minutes in aerobic and 35 m / min for 20 minutes in anaerobic) in 1 day, 3 days, 7 days and 10 days. We observed hypoxia parameters (HIF-1α content) and parameter of cardiac muscle cell structure changes (histopathological). Result Rats heart muscle underwent aerobic and anaerobic physical activity increased HIF-1 α content (p <0.05), with the highest value in day-1 and in the anaerobic group is higher than aerobic group (156.8 ± 33.1 vs. 116.03 ± 5.56). Histopathology observation showed areas of infarct in both groups in day-10. Conclusion: In rat though aerobic and anaerobic physical activity will result in heart hypoxia. The effects more severe in anaerobic than in aerobic activity. In most parameters observed, HIF-1α play important roles.

    Item Type: Book Section
    Uncontrolled Keywords: physical activity, heart muscle, hypoxia, HIF-1α
    Subjects: R Medicine > RT Nursing
    Divisions: Faculty of Medicine > Department of Nursing
    Depositing User: Sujianto Sujianto
    Date Deposited: 13 Mar 2014 14:42
    Last Modified: 14 Mar 2014 16:38
    URI: http://eprints.unsri.ac.id/id/eprint/3582

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