Analisis Pertumbuhan Kartilago Epifisialis Os Tibia Fetus Mencit(Mus musculus L.) Swiss Webster Setelah Induksi Ochratoxin A Selama Periode Organogenesis

Setiawan, Arum and Sagi, Mammed and Asmara, Widya and Istriyati, Istriyati (2012) Analisis Pertumbuhan Kartilago Epifisialis Os Tibia Fetus Mencit(Mus musculus L.) Swiss Webster Setelah Induksi Ochratoxin A Selama Periode Organogenesis. Jurnal Biologi Papua, 4 (1). pp. 25-31. ISSN 20863314

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    Abstract

    The aims of this study were determined the effects of Ochratoxin A (OTA) on growth of fetus tibia epiphyseal cartilage during organogenesis period. Twenty four pregnant mice were divided randomly into 4 groups of 6. Ochratoxin A was dissolved in sodium bicarbonateand administered orally on seventh to fourteenth days of gestation at dosage of 0.5, 1.0, 1.5 mg/kg bw, respectively. The remaining were used as control. The fetal tibia was taken after the 18 th day of pregnancy. The growth of tibia epiphyseal cartilages were observed histologically using Erlich’s Haematoxylin-Eosin Stain. The result of this study indicated that OTA caused decreased thickness of the rest zone, proliferative zone, maturation zone and calsification zone of the fetus tibial growth plate significantly.

    Item Type: Article
    Subjects: Q Science > QL Zoology
    Divisions: Faculty of Mathematics and Natural Sciences > Department of Biology
    Depositing User: Dr Arum Setiawan
    Date Deposited: 13 Oct 2013 12:54
    Last Modified: 13 Oct 2013 12:54
    URI: http://eprints.unsri.ac.id/id/eprint/2798

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