Intracellular Ca2+ Regulation in Calcium Sensitive Phenotype of Saccharomyces cerevisiae

Hermansyah, Hermansyah (2010) Intracellular Ca2+ Regulation in Calcium Sensitive Phenotype of Saccharomyces cerevisiae. HAYATI Journal of Biosciences, 17 (1). pp. 123-127. ISSN 2086-4094

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    Intracellular cytosolic Ca2+ concentration accumulation plays an essential information in Saccharomyces cerevisiae i.e. to explain cellular mechanism of Ca2+ sensitive phenotype. Disruption both S. cerevisiae PPase PTP2 and MSG5 genes showed an inhibited growth in the presence of Ca2+. On the other hand, by using Luminocounter with apoaequorin system, a method based upon luminescent photoprotein aequorin, intracellular Ca2+ concentration was accumulated as a consequence of calcium sensitive phenotype of S. cerevisiae. This fact indicated that PPase Ptp2p and Msg5p were involved in intracellular Ca2+ transport in addition their already known pathways i.e Mitogen Activated Protein Kinase cell wall integrity pathway, high osmolarity glycerol (HOG) pathway, and pheromone response FUS3 pathway.

    Item Type: Article
    Uncontrolled Keywords: Saccharomyces cerevisiae, protein phosphatase, calcium sensitivity, calcium accumulation
    Subjects: Q Science > Q Science (General)
    Q Science > QD Chemistry
    Divisions: Faculty of Mathematics and Natural Sciences > Department of Chemistry
    Depositing User: Candra Setiawan
    Date Deposited: 18 Jan 2012 13:54
    Last Modified: 01 Feb 2012 18:50

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