EFFECT OF EXON 1 CODON 52 AND 54 MANNOSE BINDING LECTIN GENE POLYMORPHISM ON THE INCIDENCE OF PULMONARY TUBERCULOSIS

K. Arrahmanda, - and Z. Ahmad, - and Sudarto, - and A. Rasyid, - and Yuwono, - (2011) EFFECT OF EXON 1 CODON 52 AND 54 MANNOSE BINDING LECTIN GENE POLYMORPHISM ON THE INCIDENCE OF PULMONARY TUBERCULOSIS. In: 16th Congress of the Asian Pacific Society of Respirology, 03 - 06 November 2011, Shanghai International Convention Center, Shanghai China.

[img]
Preview
PDF
Download (142Kb) | Preview

    Abstract

    Tuberculosis (TB) still world’s and Indonesia problem. Approximately one third of the world population ever infected with Mycobacterium tuberculosis (Mtb), but only about 10% become pulmonary TB. Presumably there is influence of individual genetic factors to TB infection. Mannose binding lectin (MBL) is an acute phase protein in a non specific immune system response which will bind Mtb and activate complement system to destroy the pathogen. Polymorphisms in exon 1 codon 52 and 54 might have correlation with decreasing of MBL protein in plasma and influence to opsonin function

    Item Type: Conference or Workshop Item (Paper)
    Subjects: R Medicine > R Medicine (General)
    Divisions: Faculty of Medicine > Department of Medicine
    Depositing User: Yon Yuwono
    Date Deposited: 25 Feb 2013 15:16
    Last Modified: 25 Feb 2013 15:16
    URI: http://eprints.unsri.ac.id/id/eprint/1784

    Actions (login required)

    View Item