Efek Asam Metoksiasetat (MAA) Terhadap Perkembangan Embrio Tahap Praimplantasi Mencit (Mus musculus) Swiss Webster

Riyanto, Riyanto (2003) Efek Asam Metoksiasetat (MAA) Terhadap Perkembangan Embrio Tahap Praimplantasi Mencit (Mus musculus) Swiss Webster. Majalah Ilmiah Sriwijaya, 36 (1). pp. 67-72. ISSN 0126-4680

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    Abstract

    The effects of methoxyacetic acid on preimplantation stage embryos of Swiss Webster mice (Mus musculus) have been studied. Female mice were superovulated with 5 I.U. of PMSG (Folligon) and 5 I.U. of hCG (Chorulon) and were mated with male mice overnight. A veginal plug detected at the following morning was confirmed as day 0 of gestation. On gestation day 2, mice were administered with MAA dose 2.5 mmol/kg bw by gevage. On gestation day 3.5 mice were sacrificed for embryo collection. The result showed that MAA could decrease significantly (p<0,05) the number of embryos that reached late blastocysts, this was caused by significant increase (p<0,05) of the percentege of embryos that could only reach the morula stage. It could be concluded, that the administration of MAA on gestation day 2 inhibit the developmental of preimplantation embryos, proven by the decrease of percentage of embryos that reached late blastocysts stage caused by developmental retardation, especially on the morula stage.

    Item Type: Article
    Additional Information: sifat teratogenik MAA terhadap embrio mencit
    Uncontrolled Keywords: Asam Metoksiasetat (MAA), Embrio dan Mencit
    Subjects: Q Science > QL Zoology
    Divisions: Faculty of Teacher Training and Science Education > Department of Mathematics and Sciences Education > Biology Education
    Depositing User: riyanto Ry yanto
    Date Deposited: 04 Feb 2013 09:07
    Last Modified: 04 Feb 2013 09:07
    URI: http://eprints.unsri.ac.id/id/eprint/1627

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